The dietary flavonoid phloretin modulates Ca2+-activated K+ channels resulting in an increase of endothelial Nitric Oxide production. | [International Journal of Pharmacology • 2005]

Author(s):

1. B. M. Minz: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

2. G. M. Bauer: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

3. C. A. Schaefer: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

4. A. Erdogan: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

5. H. Tillmanns: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

6. B. Waldecker: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

7. C. R. W. Kuhlmann: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

8. J. Wiecha: Department of Cardiology and Angiology, Justus-Liebig-University of Giessen, Germany

Abstract:

The aim of this study was to investigate the effects of phloretin on the Ca2+-activated K channel with large conductance (BKca) and to assess a possible contribution of the BK, to phloretin-induced changes of endothelial proliferation and Nitric Oxide (NO) production. In this study the patch-clamp technique was used to perform single channel recordings of the BKca in cultured endothelial cells derived from Human Umbilical Cord Veins (HUVEC). BKca open state probability (NPo) was significantly increased after 5 min of continuous perfusion with 80 µmol L-1 phloretin (14 fold increase at a pipette potential of 100 mV; n=31, p

Page(s): 38-43

DOI: DOI not available

Published: Journal: International Journal of Pharmacology, Volume: 1, Issue: 1, Year: 2005

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