The role of probiotic in preventing recurrent urinary tract infections in pregnant women | [Biomedica • 2024]

Author(s):

1. Sadia Kazi: Department of Pharmacology, Isra University, Hyderabad, Pakistan.

2. Saif Ur Rehman: Department of Pharmacology, Isra University, Hyderabad, Pakistan.

3. Sara Jamil Khan: Department of Pharmacology, Isra University, Hyderabad, Pakistan.

4. Shuja Anwar Kazi: Department of Pharmacology, Isra University, Hyderabad, Pakistan.

5. Saadia Zainab: Department of Pharmacology, Isra University, Hyderabad, Pakistan.

6. Shahnaz Bano: Department of Pharmacology, Isra University, Hyderabad, Pakistan.

Abstract:

Background and Objective: Urinary tract infections (UTIs) are a major public health disease aeftr upper respiratory tract infections, aefcting more than 150 million people worldwide The study was aimed to identify the eefcts of probiotics in preventing recurrent UTIs in pregnant women. Methods: This randomized controlled trial was conducted on pregnant females (1st and 2nd trimester), aged between 18 and 40 years presenting with UTIs. A total of 60 participants were equally and randomly allocated into two groups, i.e., Group A, who received probiotics along with conventional treatment, and Group B which acted as a control and received the placebo along with the conventional treatment. Urine D-R evaluations were performed pre and post intervention. The pre-post analysis was performed using a paired t-test as the data were normally distributed. To compare analysis among groups, an independent sample t test was applied. p (<0.05) was considered as statistically significant. Results: Group-A (Probiotic) showed greater improvement among variables where the Leukocyte count improved from 15.2 ± 4.3 (cells/ HPF) to 10.5 ± 3.1 (cells/HPF) (p = 0.001), and the level of nitrites improved from 0.8 ± 0.2 to 0.5 ± 0.1µmol/ml (p = 0.02) as compared to Group-B (p = 0.05). Conclusion: The addition of probiotics in the conventional treatment regimen in pregnant females with recurrent UTIs leads to earlier recovery as depicted by the clinico-pathological assessment.

Page(s): 130-134

DOI: 10.24911/BioMedica/5-1183

Published: Journal: Biomedica, Volume: 40, Issue: 3, Year: 2024

Keywords:

Urinary tract infection , Probiotics , prevention , treatment , Probiotics , Pregnant females

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