The Role of Nerve Growth Factor (NGF) and Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Tic Disorders. | [Pakistan Journal of Medical Sciences • 2018]

Author(s):

1. Ali Karayagmurlu: Department of Child and Adolescent Psychiatry, Gaziantep Maternity and Child Health Hospital Gaziantep, Turkey

2. Hakan Ogutlu: Department of Child and Adolescent Psychiatry, Erzincan University Faculty of Medicine, Erzincan, Turkey.

3. Ibrahim Selcuk Esin: Department of Child and Adolescent Psychiatry, Ataturk University Faculty of Medicine, Erzurum, Turkey

4. Onur Burak Dursun: Department of Child and Adolescent Psychiatry, Ataturk University Faculty of Medicine, Erzurum, Turkey

5. Ahmet Kiziltunc: Department of Medical Biochemistry, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Abstract:

Objectives: Tic disorders are associated with neurodevelopmental origin, changes in dopaminergic neurons, and the formation of immunoreactivity, it is thought that neurotrophic factors may be crucial in the emergence of tic disorders. In this study, we targeted to explore role of neurotrophic factors in tic disorders. The aim of this study was to investigate serum Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Nerve Growth Factor (NGF) levels in patients with tic disorder and healthy controls. Methods: Thirty-four children, constituted the case group, were diagnosed with tic disorder. The control group included 34 healthy children. Development and Well-Being Assessment (DAWBA) (structured interview) and Yale Global Tic Severity Rating Scale (YGTSRS) was applied to the patients. NGF and GDNF levels were measured with ELISA kit. Results: In case group, serum NGF and GDNF levels were found to be significantly higher in females than males (p = 0.042, p = 0.031). It was determined that serum NGF and GDNF levels were correlated with each other (r = 0.803, p <0.001) and there were no correlations between other parameters. There was no significant difference in NGF and GDNF in patients with tic disorder, compared to healthy controls. Conclusions: The absence of this relationship does not exclude the hypothesis that neurotrophic factors may play a role in the etiopathogenesis of tic disorders.

Page(s): 844-848

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 34, Issue: 4, Year: 2018

Keywords:

Tic Disorder , Nerve Growth Factor NGF , Glial Cell LineDerived Neurotrophic Factor GDNF

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