The efficacy of cognitive behavioral therapy in addition to pharmacotherapy versus pharmacotherapy alone in the treatment of major depressive disorder in the Pakistani population | [Pakistan Journal of Medical and Health Sciences • 2022]

Author(s):

1. ALI BUX RAJPER: Ghulam Muhammad Mahar Medical College,Sukkur, Pakistan

2. JAWED AKBER DARS: Jinnah Postgraduate Medical Center (JPMC),Karachi, Pakistan

3. FARIHA IQBAL: Shifa,, Pakistan

4. GHULAM RASOOL: The Tree House Psychiatry Clinic,Rawalpindi,Pakistan

5. CHOONI LAL: Jinnah Postgraduate Medical Center (JPMC),Karachi,

6. MUZAMIL HYDER: Jinnah Postgraduate Medical Center Karachi,, Pakistan

7. MUHAMMAD IQBAL AFRIDI: Jinnah Postgraduate Medical Center Karachi,, Pakistan

8. FAREED ASLAM MINHAS: The Tree House Psychiatry Clinic,Rawalpindi,Pakistan

9. KIRAN ABBAS: Department of Public Health Aga Khan University Hospital, Pakistan

Abstract:

Objective: To access the efficacy of cognitive behavioral therapy (CBT) in addition to pharmacotherapy versus pharmacotherapy alone in the treatment of major depressive disorder Methodology: A case-control study was conducted at different psychiatric clinics in Pakistan between April 2019 to October 2020. All participants with depression were divided into two groups; Group A patients were treated in compliance with the current treatment guidelines for antidepressant pharmacotherapy whereas patients in Group B were managed with CBT which included 15 individual 45 minutes sessions in addition to pharmacotherapy. The efficiency of the treatment was assessed on PHQ-9, with treatment being considered successful in patients with a significantly improved score. Results: 53.80% participants of Group A and 37.50% participants of Group B with moderate depression suffered a depressive episode within the last 12 months whereas 46.20% participants of Group A and 62.50% participants of Group B with moderate depression suffered a depressive episode the last 12 months. However, 49.50% participants of Group A and 83.30% participants of Group B with moderately severe depression suffered a depressive episode within the last 12 months whereas 50.50% participants of Group A and 16.70% participants of Group B with Moderately severe depression suffered a depressive episode the last 12 months. Escitalopram was the most common prescribed antidepressant (44.8%). Conclusion: It was found that CBT in addition to Pharmacotherapy was more effective in moderate depression whereas Pharmacotherapy alone was much more effective in Moderately Severe depression.

Page(s): 444-447

DOI: 10.53350/pjmhs22161444

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 16, Issue: 1, Year: 2022

Keywords:

CBT , Major depressive disorder , Cognitive Behavioral Therapy , PHQ9 , Pharmacotherapy

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