Synthesis, spectroscopic characterization and antimicrobial activities of N-methyl-o- methoxybenzohydroxamic acid and its metal (Fe, Co, Ni, Zn) complexes | [Pure and Applied Biology • 2021]

Author(s):

1. Saifullah: Chemistry Department, University of Balochistan, Quetta , Pakistan

2. Naqeeb ullah Khan: Chemistry Department, University of Balochistan, Quetta , Pakistan

3. Samiullah: Chemistry Department, University of Balochistan, Quetta , Pakistan

4. Irshad Ali: Chemistry Department, University of Balochistan, Quetta , Pakistan

5. Nizam ud Din Baloch: Chemistry Department, University of Balochistan, Quetta , Pakistan

6. Waheed Ahmed Shah: Chemistry Department, University of Balochistan, Quetta 87300-Pakistan

7. Abdul Ghaffar: Chemistry Department, University of Balochistan, Quetta , Pakistan

Abstract:

A reportedly synthesized ligand, N-methyl-o- methoxybenzohydroxamic acid (Nmombha), and its freshly prepared transition metal (Iron, Cobalt, Nickel, and Zinc) complexes have been synthesized. For characterization of reportedly synthesized ligand and its freshly prepared coordination compounds, spectroscopic techniques like Fourier transform infrared and ultraviolet/visible spectroscopy have been used. Spectroscopic studies show that the ligand acts as a bidentate chelate which forms a ring-like structure. The coordination of synthesized ligand with transition metals is via O, O donor sites, and it forms a fivemembered chelating ring on complex formation. Antimicrobial activities such as antibacterial and antifungal activities have been done for the said ligand and its complexes. Antibacterial activity of the synthesized ligand and its metal complexes are examined against four different species of Gram-positive and Gram-negative bacterial strains including Staphylococcusaureus, Klebsieludla, Esherichia coli, and Pseudomonas. Comparing the antibacterial effectiveness, the metal complexes having greater lipophilicity character show much higher antibacterial efficiency when compared with the free ligand. Cytotoxicity evaluation of the compounds shows that some of the samples are highly cytotoxic.

Page(s): 225-233

DOI: 10.19045/bspab.2021.100023

Published: Journal: Pure and Applied Biology, Volume: 10, Issue: 1, Year: 2021

Keywords:

metal complexes , FTIR , Hydroxamic acid , Brine shrimp lethality

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views