Total skin electron beam therapy (tsebt) in management of mycosis fungoides: a case series | [Journal of Pakistan Medical Association • 2022]

Author(s):

1. Sehrish Abrar: Department of Oncology, Aga Khan University Hospital,Karachi,Pakistan

2. Bilal Mazhar Qureshi: Department of Oncology, Aga Khan University Hospital,Karachi,Pakistan

3. Asim Hafiz: Department of Oncology, Aga Khan University Hospital,Karachi,Pakistan

4. Nasir Ali: Department of Oncology, Aga Khan University Hospital,Karachi,Pakistan

5. Agha Mohammad Hammad Khan: Department of Oncology, Aga Khan University Hospital,Karachi,Pakistan

6. Ahmed Nadeem Abbasi: Department of Oncology, Aga Khan University Hospital,Karachi,Pakistan

Abstract:

A retrospective review was conducted In Aga Khan University from January 2013-December 2020 for patients who received Total Skin Electron Beam Therapy (TSEBT) on the management of Mycosis Fungoides (MF). The clinical response rate and disease-free interval (DFI) was evaluated for three patients. All of the patients received a 3600 cGy dose of radiation. Clinical complete remission (cCR) was observed in two out of three patients, while one patient showed clinical partial response. Following the cCR to TSEBT, the DFI of the first patient with stage 1B lasted 30 months, while the second patient with stage IIB remained disease free for five months. TSEBT is an effective treatment for MF disease. It can thus be expected that patients with limited disease in the early stage can acquire a cCR with a longer DFI. The clinical outcomes of our study show concordance with the literature. The patients who had extensive (T3) skin involvement and had refractory diseases showed lower DFI with radiation.

Page(s): 1208-1210

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 72, Issue: 6, Year: 2022

Keywords:

Mycosis fungoides , Modified Stanford technique , Total skin electron beam therapy , Clinical Response Rate , Diseasefree interval

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