A cross sectional study to assess the spectrum of inherited thrombophilia in adult (20 to 50 years of age). | [Isra Medical Journal • 2012]

Author(s):

1. Kiran Tauseef: Department of Haematology Al-Nafees Medical College Isra University, Islamabad Campus, Pakistan

2. Humaira Zafar: Department of Haematology Al-Nafees Medical College Isra University, Islamabad Campus, Pakistan

3. Afroz S. Kazi: Department of Haematology Al-Nafees Medical College Isra University, Islamabad Campus, Pakistan

4. Jaleel Anwar: Department of Haematology Al-Nafees Medical College Isra University, Islamabad Campus, Pakistan

Abstract:

OBJECTIVES: The aims and objectives of the study were to identify the patients with hereditary predisposition for thromboembolism and to assess the distribution of natural anticoagulants deficient in such patients. METHODS: It was a descriptive cross sectional study. Ascreening test ProC Global was carried out to detect deficiency of protein C or S and then susceptibility of protein C and protein S assays were carried out on the positive cases. The level of antithrombin and the screening test for factor V Leiden were carried out separately. RESULTS: A total of 264 patients were referred for ProC Global out of which 25 (39.0 %) were positive. The protein C was deficient in 3 patients detected by protein C assay and no patient was deficient in protein S. Antithrombin deficiency was detected in 16 out of 190 (8.4 %) patients and screening test for factor V Leiden was positive in three out of 30 (10 %) cases. CONCLUSION: Inherited thrombophilia is common in patients having a positive history of arterial or venous thrombosis.

Page(s): 5-8

DOI: DOI not available

Published: Journal: Isra Medical Journal, Volume: 4, Issue: 1, Year: 2012

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