Antidiabetic and Antimicrobial Properties of Some High Altitude Medicinal Plants of Nepal | [Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences • 2019]

Author(s):

1. Rachana Regmi: Central Department of Microbiology, Tribhuvan University,Kirtipur, Kathamandu,Nepal

2. Mitesh Shrestha: Research Institute for Bioscience and Biotechnology,Ekantakuna, Lalitpur,Nepal

3. Megha Raj Banjara: Central Department of Microbiology, Tribhuvan University,Kirtipur, Kathamandu,Nepal

4. Deegendra Khadka: Nepal Academy of Science and Technology,Khumaltar, Lalitpur,Nepal

Abstract:

Regarding severe side effects caused by synthetic drugs, studies were carried out taking high altitude medicinal plants to evaluate antidiabetic and antimicrobial activities. Antidiabetic property was measured by the inhibition protein tyrosine phosphatase 1B (PTP1B) enzyme with plant extract taking p-nitrophenyl phosphate (pNPP) as a substrate in the assay. For antimicrobial activity, plant extracts were tested against four pathogenic bacteria; Staphylococcus aureus, Escherichia coli, Klebisella pneumonia and Pseudomonas aeruginosa. BA17 appeared to be more effective for the inhibition PTP1B enzyme (95-100%) at various concentrations. BU17 showed the maximal zone of inhibition of 16 mm on three microbes in S. aureus, E. coli, and K. pneumonia at 100 mg/mL.

Page(s): 69-74

DOI: DOI not available

Published: Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 56, Issue: 3, Year: 2019

Keywords:

Medicinal plants , Type 2 diabetes mellitus , High altitude , Antimicrobial , Protein Tyrosine Phosphatase 1B

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