Behavioral Benefits of Camel Milk in Subjects with Autism Spectrum Disorder. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2015]

Author(s):

1. LailaY AlAyadhi: Department of Physiology/ Autism Research and Treatment Center, King Saud University, Riyadh, Saudi Arabia

2. Dost Muhammad Halepoto: Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

3. Abdul M. AL-Dress: Department of Physiology/ Autism Research and Treatment Center, King Saud University, Riyadh, Saudi Arabia

4. Yasmine Mitwali: Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

5. Rana Zainah: Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Abstract:

Objective: To investigate the possible therapeutic effects of camel milk on behavioral characteristics as an interventional strategy in autistic children. Study Design: Double-blind, Randomized Clinical Trial (RCT). Place and Duration of Study: Autism Research and Treatment Center, Al-Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2012 to May 2013. Methodology: Changes in behavioral characteristics in 65 (boys=60, girls=5) children with autism (aged from 2 to 12 years) were assessed. The behavioral symptoms were evaluated by Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Treatment Evaluation Checklist (ATEC) before and after the 2 weeks of camel milk therapy. Results: Significant differences were detected on Autism Spectrum Disorder (ASD) by CARS, SRS and ATEC scales, following 2 weeks of camel milk consumption, but not in the placebo group. Conclusion: The present study demonstrates that camel milk could be very promising therapeutic intervention in ASD. Further wide scale studies are strongly recommended.

Page(s): 819-823

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 25, Issue: 11, Year: 2015

Keywords:

Autism spectrum disorder ASD Camel milk Behavioral symptoms

References:

[1] 2000.Diagnostic and statistical manual of mental disorders, text revision, -

[2] EnstromAM,Van de WaterJA,AshwoodP., 2009.Autoimmunity in autism,Curr Opin Investing Drugs 10 463 -73

[3] MostafaGA,Al-AyadhiLY, 2012.The relationship between the increased frequency of serum antineuronal antibodies and the severity of autism in children,Eur J Paediatr Neurol 16 464 -8

[4] JyonouchiH,SunS,ItokazuN., 2002.Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorders,Neuropsychobiology 46 76 -84

[5] AgrawalRP,JainS,ShahS,ChopraA,AgarwalV, 2011.Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trial,Eur J Clin Nutr 65 1048 -52

[6] SaltanatH,LiH,XuY,WangJ,LiuF,GengXH, 2009.The influences of camel milk on the immune response of chronic hepatitis B patients,Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25 431 -3

[7] ShaboY,BarzelR,MargoulisM,YagilR, 2005.Camel milk for food allergies in children,Immunol Allergies 7 796 -8

[8] BashirS,Al-AyadhiLY, 2014.Effect of camel milk on thymus and activation-regulated chemokine in autistic children: doubleblind study,Pediatr Res 75 559 -63

[9] MillwardC,FerriterM,CalverS,Connell-JonesG, 2008.Gluten and casein-free diets for autistic spectrum disorder,Cochrane Database Syst Rev 2 CD003498 -

[10] SunZ,CadeRJ,FreglyMJ,PrivetteMR, 1999.-Casomorphin induces fos-like immunoreactivity in discrete brain regions relevant to schizophrenia and autism,Autism 3 67 -83

[11] RelliniE,TortolaniD,TrilloS,CarboneS,Montecchi , F., 2004.Childhood autism rating scale (CARS) and autism behavior checklist (ABC) correspondence and conflicts with DSM-IV criteria in diagnosis of autism,J Autism Dev Disord 34 703 -8

[12] ConstantinoJN,DavisSA,ToddRD,SchindlerMK,GrossMM,BrophySL, 2003.Validation of a brief quantitative measure of autistic traits: comparison of the social responsiveness scale with the autism diagnostic interview-revised,J Autism Dev Disord 33 427 -33

[13] RimlandB,EdelsonM., 2000.The Autism Treatment Evaluation Checklist (ATEC),Autism Research Institute -

[14] EberleinV.,Ludwig-Maximilians-Universität München, 2007.Hygienic status of camel milk in Dubai (United Arab Emirates) under two different milking management systems,Ph.D Thesis -

[15] ElagamyI., 2000.Effect of heat treatment on camel milk proteins with respect to antimicrobial factors: a comparison with cows' and buffalo milk proteins,Food Chemistry 68 227 -32

[16] Al-AyadhiLY,MostafaGA, 2012.A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children,J Neuroinflammation 9 54 -

[17] RoseS,MelnykS,PavlivO,BaiS,NickTG,FryeRE, 2012.Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain,Transl Psychiatry 10 e134 -

[18] ShaboY,YagilR, 2005.Etiology of autism and camel milk as therapy,Int J Disabil Hum Dev 67 -70

[19] ShaboY,YagilR, 2005.Behavioral improvement of autistic children following drinking camel milk, treating persons with brain damage,4th National Conference TelAviv -

[20] AgrawalRP,SahaniMS,TutejaFC, 2005.Hypoglycemic activity of camel milk in chemically pancreatectomized rates: an experimental study,Int J Diab Dev Countries 25 75 -9

[21] MartinF,VolpariC,SteinkuhlerC,DimasiN,BrunettiM,BiasiolG, 1997.Affinity selection of a camelized V (H) domain antibody inhibitor of hepatitis C virus NS3 protease,Protein Engineering 10 607 -14

[22] AL-AyadhiLY,ElaminNE, 2013.Camel milk as a potential therapy as an antioxidant in autism spectrum disorder (ASD),Evid Based Complement Alternat Med 602834 -

[23] SalamiM,Moosavi-MovahediF,EhsaniMR,YousefiR,Niasari-NaslajiA,Moosavi-MovahediAA, Iran 2010.Functional properties of bioactive peptides produced from camel milk,Camel and Biomolecular Sciences -

[24] SharifizadehA,SabouryAA,Moosavi-MovehediAA, Iran 2010.The role of temperature on self-association of beta-caseins from camel and bovine milk,Camel and Biomolecular Sciences -

[25] KappelerS,FarahZ,Puhan , Z., 1998.Sequence analysis of camelus dromedarius milk caseins,J Dairy Res 65 209 -22

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