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The shrinkage effect of formalin on renal cell carcinoma: Does it change the stages
Author(s):
1. Murat Akgul: Department of Urology, Tekirdag Namik Kemal University, Tekirdag, Turkey
2. Aysegul Isal Arslan: Department of Pathology, Tekirdag Namik Kemal University, Tekirdag, Turkey.
3. Cenk Yazici: Department of Urology, Tekirdag Namik Kemal University, Tekirdag, Turkey
4. Enes Altin: Department of Urology, Tekirdag Namik Kemal University, Tekirdag, Turkey
5. Meltem Oznur: Department of Pathology, Tekirdag Namik Kemal University, Tekirdag, Turkey.
Abstract:
Objective: To determine the shrinkage effect of formalin on renal cell carcinoma. Method: The retrospective study was conducted from October to November 2020 at Tekirdag Namik Kemal University, Turkey, and comprised all radical and partial nephrectomy cases performed by a single surgeon in a single clinic between January 2014 and August 2020. Pre-operative images and post-operative pathology were reviewed by the same clinician. Pre-operative longest tumour diameter of radiological images and pathological specimens measured after formalin fi xation shrinkage were compared, and the effect of the difference between the two measurements on the circumference of the tumour was examined. The formalin-related shrinkage rates of renal tumours according to the tumour size and the tumour types were also analysed. Data was analysed using SPSS 20. Results: Of the 101 cases, 58(57.4%) were of radical and 43(42.6%) of partial nephrectomy. Also, there were 77(76.2%) renal cell carcinoma cases, 22(21.8%) benign renal tumours and 2(1.9%) had other malignant tumours. There were 59(58.4%) males and 42(41.6%) females with an overall mean age of 58.1±12,2 years (range: 30-82 years). The mean radiological size of the renal tumours was 55.3±30.4 mm and it was 52.9±31.6 mm at pathological examination (p>0.05). Conclusion: Formalin fi xation of tissues post-surgery caused a difference between the radiological and pathological dimensions. Though the difference was no signifi cant, under-staging due to the shrinkage post-surgery should be considered.
Page(s): 5-7
Published: Journal: Journal of Pakistan Medical Association, Volume: 72, Issue: 11, Year: 2022
Keywords:
formalin , radiological dimension , Tissue shrinkage , Pathological dimension , Renal tumours
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