Abstract:
Background: B- type natriuretic peptides (BNP) were initially discovered in the porcrine brain, but the highest levels were reported in heart. It is a peptide with 32 aminoacids and is synthesized from the left ventricle as a result of increased myocardial wall stress. There is sufficient data in support of its cardiac damage contribution in the cardio vascular disease (CVD) but does it work in the development of chronic kidney disease (CKD) associated CVD is yet unclear that is why we planned to investigate its relation with the primary cardiac insult in CKD patients by executing a case control study. A case control study was carried out on 140 male and female subjects with chronic kidney disease especially secondary to hypertensive and diabetic nephropathy. Demographics and case history of patients were noted on a performa and categorize patients in to groups according to base line levels of Glomerular filteration rate (GFR) as defined by the classification of the national kidney foundation. The BNP levels of these patients and controls were recorded and correlate to lipid profile for the assessment of cardiac risk ratio in these patients Out of 210 subjects, 70 served as controls while 140 were CKD patients. The results showed mean ranks of TC levels in cases, 158.2mg%, where as in controls it was 131.6mg% with significance of p-value ?0.025, Similarly for lipid profile the difference in case-control values found statistically significant as LDL(p?0.05), HDL (p?0.0001), TG (p?0.05), while the deterioration in renal function measured through blood urea (p?0.0001), and creatinine (p?0.0001) found also significant in CKD patient. BNP levels in CKD population were measured significantly higher (p?0.005) as matched with those of controls. This study is helpful in identifying the risk population at the right time to initiate the preventive measures. The findings showed a set BNP value to start prophylactic therapy thus would delay the cardiac disease onset and its complications.
Page(s):
198-203
DOI:
DOI not available
Published:
Journal: Bioscience Research, Volume: 19, Issue: 1, Year: 2022
Keywords:
CKD
,
BNP
,
GFR
,
Cardiac risk ratio