Essential oils of Tetraclinis articulata and Pinus halepensis improveß -Amyloid 1-42-Induced memory impairment and oxidative stress in the rat hippocampus of Alzheimer`s disease. | [Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 • 2023]

Author(s):

1. Fatima Zahra Sadiki: Department of Chemistry, Faculty of Sciences of Meknes, Moulay Ismail University, Morocco

2. Mostafa El Idrissi: Department of Chemistry, Faculty of Sciences of Meknes, Moulay Ismail University, Morocco

3. Paula Alexandra Postu: Department of Chemistry, Faculty of Sciences of Meknes, Moulay Ismail University, Morocco

4. Oana Cioanca: Department of Pharmacognosy, Faculty of Pharmacy, University of Medicine and Pharmacy “Gr. T. Popa”, Iasi, Romani

5. Adriana Trifan: Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Romania

6. Mohammed Sbiti: Faculty of Medicine and Pharmacy of Fez, Fes, Morocco

7. Lucian Hritcu: Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Romania

Abstract:

Many new drugs derived from secondary plant metabolites have been applied for the treatment and prevention of various diseases. Essential oils are widely used as antioxidants for the prevention and treatment of various human diseases such as neurodegenerative disorders including Alzheimer`s disease. The objectives of our work were therefore, to evaluate, in vitro, the antioxidant activity and to examine, in vivo, the neuroprotective effects in rats with Alzheimer`s disease induced byß-amyloid (1-42) of essential oils from Pinus halepensis Mill. and Tetraclinis articulata (Vahl) Masters. The essential oils were extracted by the hydrodistillation technique using a Clevenger type apparatus. Subsequently, in vitro, antioxidant activity was evaluated by two methods: the DPPH free radical scavenging test and the ABTS test. Based on the results, both oils tested have an important antioxidant potential. Also, we demonstrated that our essential oils reversed the Aß1-42-induced decreasing of the spontaneous alternation in the Y-maze test and the Aß1-42-induced increasing of the working and reference memory errors in the radial arm maze test. Biochemical estimates of brain homogenates for acetylcholinesterase and biomarkers of oxidative stress were also performed. Furthermore, the oxidant-antioxidant status in the rat hippocampus was recovered after treatment with essential oils. These results suggest that the essential oils of P. halepensis and T. articulata have neuroprotective activity and can be considered as a therapeutic tool for the mitigation of amyloid Aß toxicity and neuronal dysfunction.

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Published: Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023

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