The in vitro study of interaction between antacids and anti-diabetic drug sitagliptin in the treatment of type II diabetes | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Nargis Tabassum: Department of Chemistry, Federal Urdu University of Arts, Science and Technology,Karachi,Pakistan

2. Arfa Akram: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology,Karachi,Pakistan

3. Azizuddin: Department of Chemistry, Federal Urdu University of Arts, Science and Technology,Karachi,Pakistan

4. Ateka Ahmed: Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi,Karachi,Pakistan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology,Karachi,Pakistan

5. Muhammad Naseem Khan: Microbiology Section, FMRRC, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi, Pakistan

6. Rashid Ali Khan: Pharmaceutical Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex,Karachi,Pakistan

7. Iffat Azeem: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology,Karachi,Pakistan

8. Mehwish Furrukh: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology,Karachi,Pakistan

Abstract:

Hyperglycemia is a long-lasting syndrome that occurs either when the pancreas cannot produce enough insulin, or the body cannot effectively utilize that insulin to regulate blood sugar levels. Non-insulin-dependent hyperglycemia, also known as type II diabetes, causes a common consequence of severe damage to many of the body's organs mainly the blood vessels and nerves. The majority of people around the world are suffering from non-insulindependent diabetes. The present work showed a great effort to investigate any possible interaction between antacids and sitagliptin (anti-diabetic drug) in the treatment of type II diabetes with gastrointestinal tract problems. The in vitro studies were carried out in simulated gastric juice pH 2.0 and intestinal pH 7.4 at 37°C. MgCO3, NaHCO3, Mg(OH)2, Al(OH)3 and CaCO3 were used as antacids in these studies. It has been observed that % release of sitagliptin was significantly enhanced in the presence of calcium carbonate and magnesium carbonates.

Page(s): 373-378

DOI: 10.36721/PJPS.2

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: 2, Year: 2023

Keywords:

Diabetes , Hyperglycemia , Diabetes , Sitagliptin , antacid , antidiabetic agent

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