Benzoylsalireposide an antioxidant, lipoxygenase and chymotrypsin inhibitor. | [Proceedings of Pakistan Academy of Sciences • 2005]

Author(s):

1. Attaur Rahman: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

2. M. Iqbal Choudhary: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

3. Talat Makhmoor: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

4. Muhammad Arif Lodhi: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

5. Sarfraz A. Nawaz: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

6. Umar Farooq: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

7. Muhammad Abid Rashid: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

8. Muhammad Zubair: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

9. Viqar Uddin Ahmad: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

10. Muhammad Athar Abbasi: HEJ Research Institute of Chemisty, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan

Abstract:

Two phenolic glycosides, benzoylsalireposide (1) and salireposide (2) were isolated from Symplocos racemosa Roxb, which showed DPPH radical scavenging activity, with the IC50 values of 773 ± 11.83 µM and 757 ± 0.374 µM respectively. In addition to this, compound 1 also displayed in vitro inhibitory potential against lipoxygenase and chymotrypsin in a concentration-dependent fashion with the IC50 values of 75.1 ± 0.5 µM and 65.07 ± 0.10 µM respectively, while 2 was inactive against these enzymes.

Page(s): 121-124

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 42, Issue: 2, Year: 2005

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