Uric Acid is Associated with Both, Xanthelasmata and Dyslipidemia. | [Journal of Medical Science • 2017]

Author(s):

1. Wazir Mohammad Khan: Department of Medicine, Khyber Teaching Hospital, Peshawar - Pakistan

2. Abidullah Khan: Department of Medicine, Khyber Teaching Hospital, Peshawar - Pakistan

3. Majid Khan: Department of Medicine, Khyber Teaching Hospital, Peshawar - Pakistan

4. Maimoona Ayub: Department of Medicine, Khyber Teaching Hospital, Peshawar - Pakistan

5. Azer Rashid: Department of Dermatology, Khyber Teaching Hospital, Peshawar - Pakistan

Abstract:

Objective: To assess the association of uric acid with both, xanthelasma and the fasting blood lipids. Material and Methods: This cross-sectional study was conducted in the Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan from January 2015 to July 2016 and included 60 cases with xanthelasma palpebrarum (XP) as the study group, and 60 age and sex matched individuals without xanthelasma palpebrarum (WXP), as the control group. Each participant had his/her fasting lipid profile determined, along with serum uric acid. The data was analyzed using SPSS version 16. Independent t-test and Pearson correlation tests were applied. Results: The values of uric acid, fasting total cholesterol, LDL-C and TGs were higher, and HDL-C lower, in the XP group, than in WXP group, (P <0.001). Serum uric acid correlated positively with serum total cholesterol, triglycerides and LDL-C (P <0.001), and negatively with HDL-C, (P < 0.001). Moreover, fasting cholesterol level was higher in XP group (M=208.32, SD=17.135), than WXP group (M=177.28, SD=8.203), at a statistically significant level of, t (84.69) =12.65, P <0.001, Cohen's D=2.31. Conclusion: Serum uric acid is higher in subjects with xanthelasmata. Moreover, serum uric acid has a positive correlation with both; LDL-c and TGs, but an inverse relation with HDL-c.

Page(s): 167-170

DOI: DOI not available

Published: Journal: Journal of Medical Science, Volume: 25, Issue: 1, Year: 2017

Keywords:

Keywords are not available for this article.

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