An Unusual Case of Megacolon Due to Sarcocystis Spp. Infection and Local Amyloidosis in a Husky Dog. | [Pakistan Veterinary Journal • 2015]

Author(s):

1. Carmen Solcan: Ion Ionescu de la Brad, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine,M. Sadoveanu Alley 8, 700489 Iași,Romania

2. Dumitru Acatrinei: Ion Ionescu de la Brad, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine,M. Sadoveanu Alley 8, 700489 Iași,Romania

3. Viorel Floristean: Ion Ionescu de la Brad, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine,M. Sadoveanu Alley 8, 700489 Iași,Romania

4. Gheorghe Solcan: Ion Ionescu de la Brad, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine,M. Sadoveanu Alley 8, 700489 Iași,Romania

5. Bogdan Gabriel Şlencu: Grigore T. Popa, University of Medicine and Pharmacy, Faculty of Pharmacy,Universităţii Street 16, 700115 Iași,Romania

6. Mircea Fântânariu: Ion Ionescu de la Brad, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine,M. Sadoveanu Alley 8, 700489 Iași,Romania

Abstract:

A four-year old Husky dog suffering of chronic diarrhea was radiologically diagnosed with megacolon and consequently, partial resection of the colon wall was performed. Histological examination of the colonic wall revealed the presence of Sarcocystis spp. oocysts. Chronic inflammation of colonic mucosa resulted in local amyloidosis, overexpression of Bcl-2 in the goblet cells, which suggested decreased apoptosis and increased mucous cells population in Lieberkühn's glands. The expression of immunoglobulin A (IgA) was reduced intra-epithelially and increased in blood capillaries, periglandulary and in the submucosal stroma consequently to parasitic infection. The colonic mucosa showed plasma cells, eosinophilic, mast cells and lymphocytic infiltrations. The Sarcocystis chronic parasitism may cause colon chronic dilatation due to persistent inflammation of the mucosa, characterized by infiltration of lymphocytes and plasma cells followed by the synthesis of amyloid. The amyloid stored around the Lieberkühn's glands or in the submucosal stroma can cause autonomic dysfunction in Auerbach's and Meissner's plexuses and autonomic ganglia.

Page(s): 531-533

DOI: DOI not available

Published: Journal: Pakistan Veterinary Journal, Volume: 35, Issue: 4, Year: 2015

Keywords:

Amyloidosis Husky dog Megacolon Sarcocystis

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