Abstract:
Irritable bowel syndrome (IBS) is a common functionall bowel disorder of unknown aetiology It is defined by the-presence of gastrointestinal (GI) symptoms including abdominal pain/ discomfort, bloating and bowel motor dysfunction. No available therapy is yet effective against all the symptoms of the disorder. Current treatments therefore target individual symptoms but may be accompanied by unpleasant side-effects. Tegaserod is a novel selective serotonin receptor type 4 (5-HT4),partial agonist with strurctural similarity to 5-HT. Tegaserod stimulates small bowel and colonic motility and helps to normalise GI function. Clinical trials using a patient`s assessment of efficacy demonstrate that tegaserod significantly improves key symptoms of IBS: abdominal pain/discomfort, bloating and constipation. Tegaserod is well tolerated with an excellent safety profile and represents a significant treatment advance in this difficult-to-treat disorder.
Page(s):
47-51
DOI:
DOI not available
Published:
Journal: Medical Channel: Journal of Modern Dental and Medical Sciences, Volume: 10, Issue: 2, Year: 2004