Synthesis, spectral analysis and antibacterial activity of some new N-substituted sulfonamide derivatives of 1, 3-benzodioxol-5-amine. | [Pakistan Journal of Chemistry • 2015]

Author(s):

1. Aziz-ur-Rehman: Department of Chemistry, Government College University, Lahore-54000, Pakistan

2. A. Siddiqa: Department of Chemistry, Government College University, Lahore-54000, Pakistan

3. M. A. Abbasi: Department of Chemistry, Government College University, Lahore-54000, Pakistan

4. S. Z. Siddiqui: Department of Chemistry, Government College University, Lahore-54000, Pakistan

5. H. Khalid: Department of Chemistry, Government College Women University, Sialkot-51310, Pakistan

6. S. Rasool: Department of Chemistry, Government College University, Lahore-54000, Pakistan

7. I. Ahmed: Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

8. R. Malik: Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

Abstract:

1, 3-Benzodioxol-5-amine ,(1) was used as a precursor to synthesize N-alkyl/aralkyl-N-,(1,3-benzodioxol-5-yl)arylsulfonamide derivatives, 7a-b to 9a-b. The molecule 1 was reacted with arylsulfonyl chlorides, 2a-b, on stirring in a dilute aqueous sodium carbonate solution to synthesize N-,(1, 3-benzodioxol-5-yl) arylsulfonamide, 3a-b. The molecules, 3a-b, were further stirred with alkyl/aralkyl halides, 4-6, in DMF at RT to get the desired final compounds, 7a-b to 9a-b. The synthesized molecules were structurally confirmed by IR, 1H-NMR and EIMS spectral data. The antibacterial activity of these compounds rendered them moderately weak inhibitors relative to ciprofloxacin, the reference standard.

Page(s): 75-79

DOI: DOI not available

Published: Journal: Pakistan Journal of Chemistry, Volume: 5, Issue: 2, Year: 2015

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