The effect of high-fructose intake on the vasopressor response to angiotensin II and adrenergic agonists in Sprague-Dawley rats. | [Pakistan Journal of Pharmaceutical Sciences • 2013]

Author(s):

1. Mohammed Hadi Abdulla: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia; Department of Physiology, Western Gateway Building, University College Cork, College Road, Cork, Ireland

2. Munavvar Abdul-Sattar: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia

3. Nor Azizan Abdullah: Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia

4. Edward James Johns: Department of Physiology, Western Gateway Building, University College Cork, College Road, Cork, Ireland

Abstract:

Effect of losartan was assessed on systemic haemodynamic responses to angiotensin II (Ang II) and adrenergic agonists in the model of high-fructose-fed rat. Twenty-four Sprague-Dawley (SD) rats were fed for 8 weeks either 20% fructose solution (FFR) or tap water (C) ad libitum. FFR or C group received losartan (10mg/kg/day p.o.) for 1 week at the end of feeding period (FFR-L and L) respectively, then the vasopressor responses to Ang II, noradrenaline (NA), phenylephrine (PE) and methoxamine (ME) were determined. The responses (%) to NA, PE, ME and Ang II in FFR were lower (p

Page(s): 727-732

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 26, Issue: 4, Year: 2013

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views