Topical delivery of doxepin using liposome containing cream: An emerging approach in enhancing skin retention | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Ainaz Didevar Asl: School of Pharmacy, Ardabil University of Medical Sciences,Ardabil,Iran

2. Shahab Bohlooli: Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences,Ardabil,Iran

3. Masoomeh Dadkhah: Pharmaceutical Sciences Research Centre, Ardabil University of Medical Sciences,Ardabil,Iran

4. Leila Rezaie Shirmard: Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences,Ardabil,Iran

Abstract:

Conventional formulation of topical doxepin has similar antihistaminic effects as oral doxepin; however, its efficacy is limited due to poor localized effects on the skin. This study was designed to compare the ex vivo permeation and retention of two topical doxepin formulations; liposomal cream and plain cream. Methods: Doxepin-containing liposomes were prepared with the thin-film hydration method and assessed for size, size distribution, morphology, entrapment efficiency (EE%) and stability Using rat skin specimens in a Franz diffusion cell. Doxepin concentration in skin and receptor fluid was quantified by a validated HPLC method. The optimized liposomal formulation represented a uniform shape with narrow size distribution and an average diameter of 208.7±5.6nm. EE% of doxepin was 79±1.3 and the liposomes were stable at least for six weeks at 4°C. Ex vivo studies showed that while a significantly higher amount of doxepin has passed through the skin and entered the receptor compartment from conventional dosage form (47.06±2.5µg/cm2vs 11.20±0.6µg/cm2 for liposomal formulation), liposomal doxepin favoured accumulation in dermis and epidermis. These results suggest that the liposomal doxepin cream is an effective and easy-to-use formulation and may improve the cutaneous retention of doxepin, thus decreasing its systemic side effects.

Page(s): 1497-1506

DOI: 10.36721/PJPS.2023.36.5.REG.1497-1506.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: 5, Year: 2023

Keywords:

Atopic dermatitis , ex vivo study , Doxepin , liposome

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