Vitamin b12 deficiency with megaloblastic anemia: an experience at tertiary care hospital of Sindh. | [Journal of Liaquat University of Medical and Health Sciences • 2014]

Author(s):

1. Ghulam Shah Nizamani: Department of Pathology, Isra University Hyderabad, Sindh, Pakistan

2. Iqbal Ahmed Memon: Department of Medicine, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Sindh, Pakistan

3. Azhar Memon: Department of Medicine, Isra University Hospital Hyderabad, Sindh, Pakistan

4. Haji Khan Khoharo: Faculty of Medicine & Allied Medical Sciences, Isra University Hyderabad, Sindh, Pakistan

Abstract:

OBJECTIVE: To determine frequency of Vitamin B12 deficiency in subjects with anemia and elevated mean corpuscular volume. STUDY DESIGN: Cross sectional study PLACE AND DURATION: Department of Medicine, Liaquat University and Isra University Hospital Hyderabad from January 2011 to August 2013. METHODOLOGY: A sample of 113 subjects was selected according to inclusion and exclusion criteria. Serum vitamin B12 deficiency was defined as per standard criteria. Blood samples were analyzed on Sysmex KX 21 hematology analyzer. Continous variables were analyzed by ANOVA and Tukey-Cramer test while categorical variables by Chi-square test. The association between variables was analyzed by Pearson`s correlation. A p-value of ≤ 0.05 was taken statistically significant. RESULTS: Of 113 subjects, 37 (32.7%) were male and 76 (67.2%) female, mean±SD age was 34.48±6.71 years and 89.3% (n=101) were anemic. Mean hemoglobin, hematocrit and RBC counts were found as 11.3 g/dl, 33.1% and 3.0 million/μL respectively. Of total 113 subjects, vitamin B12 deficiency was noted in 65 (57.5%); further subdivided as borderline and definitive deficiency in 19.4% and 37.9% respectively. Mean corpuscular volume as high as 139 fl and vitamin B12 levels as low as

Page(s): 13-17

DOI: DOI not available

Published: Journal: Journal of Liaquat University of Medical and Health Sciences, Volume: 13, Issue: 1, Year: 2014

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