Author(s):
1. Tehmina Sohail:
Pharmaceutical Research Centre, PCSIR Labs Complex,Karachi,Pakistan
2. Hina Imran:
Pharmaceutical Research Centre, PCSIR Labs Complex,Karachi,Pakistan
3. Rashid Ali Khan:
Pharmaceutical Research Centre, PCSIR Labs Complex,Karachi,Pakistan
4. Shazia Syed:
Department of Chemistry, University of Karachi,Karachi-75270,Pakistan
Abstract:
Poly-herbal multivitamin supplement prepared by Real Herbal Laboratories Pakistan is a mixture of different medicinal plants with honey. Acute oral toxicity and efficacy studies of this poly-herbal multivitamin supplement were conducted in albino rats and rabbits respectively to assess its any toxicological/nutritional effects on general behavior, body weight, biochemical and hematological parameters. Acute oral toxicity study was carried out by adopting the OECD - 423 Guidelines. The poly-herbal product was administered orally at 300, 2000 and 5000mg/kg dose. All animals were kept under observation for 1, 2, 4 , 8 hours to monitor the signs of illness or mortality after oral administration of sample, and twice daily thereafter for 14 days. During the study, all rats were remained alive with normal appearance and showed increase in body weight. No gross lesions were observed in vital organs during autopsy. Biochemical and hematological analysis of 30days efficacy study in rabbits showed remarkable improvement in body weight and health condition of test group. There was an increase in hemoglobin level of test group animals as compared to the control group which were fed with vehicle only. White blood cells and Red blood cells count indicated that drug didn't create any adverse reaction in blood parameters. In longterm use of this poly-herbal supplement no signs of toxicity were found.
Page(s):
621-627
DOI:
DOI not available
Published:
Journal: International Journal of Biology and Biotechnology, Volume: 20, Issue: 4, Year: 2023
Keywords:
Acute oral Toxicity
,
Efficacy study
,
multivitamin supplement
,
Biochemical studies
,
Hematological analysis
References:
References are not available for this document.
Citations
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