A new analysis of isometric tension curves obtained from hypothermic and hyperthermic studies on single skeletal muscle: removal of possible fatigue effect. | [International Journal of Pharmacology • 1990]

Author(s):

1. Khairun-Nisa Shaikh: Pharmacology Department, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

2. Hilal A. Shaikh: Physiology Department, University of Karachi, Karachi, Pakistan

3. M. Abdul-Azeem: Physiology Department, University of Karachi, Karachi, Pakistan

4. S. M. Padsha: Physiology Department, College of Physicians & Surgeons, Defence Housing Society, Karachi, Pakistan

Abstract:

A new analytical method has been designed for isometric tension curves obtained from hypothermic and hyperthermic studies on single skeletal muscles for the removal of possible fatigue effect. For this purpose, rat diaphragm strips were subjected to hypothermia and the results were compared with a previous study (Shaikh et al., 1979a) to determine whether the previously observed decrease in tetanic tension was temperature dependent or that it was due to fatigue. The results showed that under hypothermic conditions, the twitch and tetanic activity was optimal at 18°C and 30°C respectively with the twitch/tetanus ratios being lower at higher temperatures and vice versa. The new method of analysis designed for the present and the previous isometric tension curves. obtained from muscles subjected to hypothermia and hyperthermia, has demonstrated the actual effect of temperature while excluding the possible fatigue effect.

Page(s): 79-88

DOI: DOI not available

Published: Journal: International Journal of Pharmacology, Volume: 7, Issue: 1--2, Year: 1990

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