The efficacy of combined topical niosomal dapsone gel and intralesional injection of meglumine antimoniate in comparison with intralesional meglumine antimoniate and cryotherapy in the treatment of cutaneous leishmaniasis | [Journal of Pakistan Association of Dermatologists • 2016]

Author(s):

1. Mahin Aflatoonian: Department of Dermatology, School of Medicine, Kerman University of Medical Sciences, Iran

2. Alireza Fekri: Department of Dermatology, Faculty of Medicine, University of Medical Sciences, Kerman, Iran

3. Zahra Rahnam: Department of Dermatology, School of Medicine, Kerman University of Medical Sciences, Iran

4. Maryam Khalili: Department of Dermatology, School of Medicine, Kerman University of Medical Sciences, Iran

5. Abbas Pardakhti: Department of Pharmaceutics, School of Pharmacy, University of Medical Sciences, Kerman, Iran

6. Payam Khazaeli: Department of Pharmaceutics, School of Pharmacy, University of Medical Sciences, Kerman, Iran

7. Kambiz Bahadini: Medical Informatics Research Center, Institute of future studies in health, Kerman University of Medical Sciences, Kerman, Iran

Abstract:

Objective To evaluate the efficacy of niosomal dapsone gel and intralesional meglumine antimoniate with cryotherapy and intralesional meglumine antimoniate in cutaneous leishmaniasis. Methods This was a randomized clinical trial with 73 participants that were divided into two groups including, case group (weekly intralesional meglumine antimoniate and twice a day niosomal dapsone gel) and control group (weekly intralesional meglumine antimoniate with biweekly cryotherapy). The treatment course continued until 16 weeks or complete cure, whatever occurred earlier and participants were followed up in 4th, 8th, 12th and 16th weeks of the treatment. Results Overall, 68 patients (33 males and 35 female) completed the study. Age, sex, size and duration of the lesions were not statistically different between two groups. At the end of the study, 82.9% of patients in case group showed complete response. Conclusion Niosomal dapsone gel has promising results with fewer adverse effects, so, it can be used as an alternative treatment modality, especially in children and patients with contraindication of systemic drugs.

Page(s): 353-360

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 26, Issue: 4, Year: 2016

Keywords:

treatment , Leishmaniasis , Topical , Dapsone , niosomal

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