Abstract:
Lung cancer is the most common cause of cancer-related deaths in humans. Early diagnosis of lung cancer with suitable treatment significantly improves the five-year survival rate. Lung cancer dysregulations imparts oxidative stress which results in important metabolic products in the form of volatile organic compounds. The noninvasive, cost-effective and simple in use analytical techniques for the detection of exhaled volatile organic compounds (VOCs), cancer biomarkers are of substantial interest for early diagnosis of lung cancer. Molecular Imprinted Polymer Based Artificial Sensors were designed for the generation of highly selective receptors for Butane and P-Xylene. Two polymer systems i.e. acrylate and polystyrene were screened out to achieve optimal sensitivity and selectivity. Artificially designed receptors were coated onto the transducer (IDEs) and change in conductance was measured by LCR meter. IDE coated by thin layer of receptors were exposed to various concentrations of templates (Butane & P-Xylene) ranging from 0-10 ppm, by using these concentrations change in signal response was recorded. In Butane At 0 ppm, conductance (Cs) measured was 0 and as for 1ppm, 2ppm, 4ppm, 6ppm, 8ppm and 10 ppm, conductance was 368nF, 512nF, 580nF, 634nF, 696nF, and 800nF. While in P-Xylene At 0 ppm, conductance (Cs) measured was 0 and as for 1ppm, 2ppm, 4ppm, 6ppm, 8ppm and 10 ppm, conductance was 154nF, 230nF, 324nF, 437nF, 596nF and 656nF respectively. Sensors showed concentration dependent linear response towards their respective template molecules. When response of polystyrene system against Butane and P-Xylene was compared with response of Acrylate system it was revealed that response of Acrylate system was greater than polystyrene system. Acrylate system-based composites were synthesized to check the response of the sensor by the addition of graphene oxide, it enhanced the surface area that leads to increase the sensitivity of sensor. The sensor was characterized by using Fourier-transform infrared spectroscopy (FTIR). Furthermore, sensor response of these Butane MIPs based sensors were investigated in the presence of competing agents/interfering analytes i.e., Butanol, Hexane and Styrene. While in the case of P-Xylene selectivity behavior was checked against Toluene, Styrene and Hexane of fabricated sensors. Each sensor responded to its template molecules only in the presence of other interfering molecules with same geometrical shape which indicate that sensors are highly selective, selective and specific.
Page(s):
0-0
DOI:
DOI not available
Published:
Journal: First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book), Volume: 0, Issue: 0, Year: 2022
Keywords:
Lung Cancer
,
biomarkers
,
Polymers
,
sensors