Cellular Stress Response Induced by Low Dose Gamma Radiation | [Proceedings of Pakistan Academy of Sciences • 2014]

Author(s):

1. Inayat ur Rahman: Gandhara College of Pharmacy, Gandhara University, Peshawar, KPK, Pakistan

2. Naeem Ullah Jan: Gandhara College of Pharmacy, Gandhara University, Peshawar, KPK, Pakistan

3. Hamid Rasul Niazi: Wazir Mohammad Institute of Paramedical Technology, Gandhara University, Peshawar, KPK, Pakistan

4. Haroon Rahim: Department of Pharmacy, Sarhad University of Science and Technology, KPK, Pakistan

Abstract:

Low dose radiation-induced damages to DNA are mainly repaired by poly (ADP-ribose) polymerase (PARP-1 and PARP-2) system present in the cell. Suppression of neoplastic transformation of human hybridcells by low doses of low linear energy transfer (LET) radiation is abrogated by PARP enzyme inhibitors andthis presents a new tool in radiotherapy for cancers. The aim of this study was to investigate DNA damages by low doses of gamma rays (2.4 mGy/h) in the presence of inhibitors, 3-aminobenzamide (3-AB) and ANI with the later showing greater increase. These results show DNA repair process reduced and the tail moment increased.

Page(s): 139-144

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 51, Issue: 2, Year: 2014

Keywords:

Gamma Radiation , 100 mGy , PARP , 24 mGy

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