Abstract:
This is a study conducted in Bahrain to find out the adverse effects of anti-tuberculous drugs on the population which has one of the highest incidence of thalassamia and haemoglobinopathy. The study was conducted on 460 patients, all were treated in the Ministry of Health Hospital from 1980 to 1983. The study showed that Isoniazid and Ethambutol are the best tolerated drugs, next come rifampicin and pyrazinamide. INAH induced neuropathy was rare. Optic atrophy was not found to any of 254 showed side effect against rifampicine, hypersensitivity to skin was the highest, next was G.I. reaction, nausea and vomiting; liver toxicity was seen in 3 out of 19. Pyrazinamide group showed 10 (8.84%) adverse reactions out of 113. Arthralgia was on top of the list, 2 patients had G.I. disturbance and 2 had liver toxicity. Streptomycin side effect was mainly on the vestibular system, 30 (10%) out of 298 showed side effects of which 19 were on the vestibular system. PAS had always been a problem to tolerate, so was Thiocetazone, both giving G.I. disturbance. We are not using PAS anymore. D-cycloserine is a reserve drug which showed psychosomatic reactions in 66% of the patients. Our result showed drug reaction to be somewhat different than the other studies, but they were not found to be related to thalassamia or haemoglobinopathy. We found Rafampicin-INAH-Pyrazinamide to be the best combination. The tolerance of these drugs is not a problem. If we are more careful, most of the patients will be able to tolerate this combination.
Page(s):
15-18
DOI:
DOI not available
Published:
Journal: Challenge, Volume: 25, Issue: 2, Year: 1984