Probiotics protect intestinal microbial dysbiosis and subsequent aero-gastric infections of Staphylococcus aureus and Pseudomonas aeruginosa | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Affhan Shoaib: Department of Biosciences, Salim Habib University, Karachi, Pakistan; Department of Biotechnology, Dalian Medical University, Dalian, P.R. China

2. Lu Xin: Department of Biotechnology, Dalian Medical University, Dalian, P.R. China

3. Yi Xin: Department of Biotechnology, Dalian Medical University, Dalian, P.R. China

Abstract:

Studies on the gut microbiome and the balance in this microbial ecosystem have been of great interest in the past decade. The human digestive tract has an immense assortment of microorganisms, and the balance in this ecological niche depends on several factors including gastric acidity and motility. Gut microbial disturbances or dysbiosis may cause an assortment of illnesses or anomalous physiological states. Infections caused by pathogens and /or exposure to antibiotics can change the gastrointestinal microbial ecosystem and create the opportunity for opportunists to overgrow and translocate to extraintestinal niches. Staphylococcus aureus and Pseudomonas aeruginosa are well-known opportunists and nosocomial pathogens. They appear to have the opportunity and the ability to promote intestinal and respiratory infections. They largely cause morbidity and mortality in both hospital and community settings. These pathogens remain the important cause of pulmonary infections in the case of Cystic fibrosis patients with a worldwide prevalence. Although antibiotics are still an effective means of treating bacterial infections, the alarming rise of multi-drug-resistant bacteria has urged us to seek new therapeutic approaches. Thus, there is a need for the development of potent antimicrobials for the effective treatment of infections. Lactobacillus and Bifidobacterium species are pulling in incredible enthusiasm as health supplements due to expanded familiarity of the beneficial roles in health and nutrition. There is evidence that maintaining a balanced intestinal microbial ecosystem can antagonize the access of respiratory and enteric pathogens. Probiotic bacteria play role in keeping the gut microbial ecosystem stable by re-establishing normal microbiota and can possibly repress pathogen’s colonization via modulation of the immune response.

Page(s): 14-14

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

probiotics , Gut microbiome , Dysbiosis

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