Abstract:
Cyprinus carpio of 4.5-5.5 gram body weights were given an anabolic-androgenic steroid, oxandrolone, per os, at a rate of 1,2,5, 5 and 10 mg/kg food for 60 days. The effect on growth, food conversion efficiency and liver, kidney brain and muscle proteins, RNA and DNA levels were observed. Muscle proximate composition was also studied. Feeding of the steroid induced significant increase in specific growth rate for weight and length and food conversion efficiency. The two parameters seemed to be related. Apart from growth increments, changes in relative weights of liver, kidney, brain and viscera were also seen. Variable changes, dependent upon the somatic growth were observed in total proteins RNA and DNA of the above mentioned organs. The molecular changes are presented in terms of ratios (RNA/DNA; protein/DNA). These ratios depict changes in cellular activities and number and size of cells. Feeding of steroid increased muscle moisture content when given in higher (5 and 10 mg/kg) doses. Total fat and ash contents of muscle decreased in all groups receiving steroid. Thirty days after the withdrawal of the steroid from the food, majority of the parameters studied were parallel to control values.
Page(s):
153-169
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Zoology, Volume: 18, Issue: 2, Year: 1986