The teratogenic profile of valproic acid (VPA) and newly synthesized derivatives in zebrafish embryos. | [International Journal of Agriculture and Biology • 2012]

Author(s):

1. Muhammad Farooq: Chair of Advanced Proteomics and Cytomics Research, College of Science, Department of Zoology, King Saud University, Riyadh - 11451, Kingdom of Saudi Arabia

2. Ayman El-Faham: Alexandria University Faculty of Science, Chemistry Department P.O. Box 426, Ibrahimia 21321 Alexandria, Egypt

3. Mohammad Ahmad: Chair of Advanced Proteomics and Cytomics Research, College of Science, Department of Zoology, King Saud University, Riyadh - 11451, Kingdom of Saudi Arabia

4. Ahmed Saad Sami: Chair of Advanced Proteomics and Cytomics Research, College of Science, Department of Zoology, King Saud University, Riyadh - 11451, Kingdom of Saudi Arabia

5. Mohammad A. Wadaan: Department of Animal Production, College of Food and Agricultural Sciences King Saud University P.O. Box 2460, Riyadh 11451, Saudi Arabia

Abstract:

In this study, the teratogenic profiles of five structural analogues of valproic acid (VPA) have been assessed in zebrafish embryos. The VPA derivatives induced severe teratogenecity in treated zebrafish embryos as compared to VPA. Moreover, three of these VPA derivatives specifically induced an undulation of notochord, which was not observed in VPA treated embryos. Variation in the treatment timings has shown that these compounds had affected the notochord cells differentiation process. Thus a new class of VPA analogues, which have affected notochord development process in zebrafish embryos by modulating the notochord cells differentiation and expansion, has been reported in this paper.

Page(s): 894-900

DOI: DOI not available

Published: Journal: International Journal of Agriculture and Biology, Volume: 14, Issue: 6, Year: 2012

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