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A convenient synthesis of bioactive 5-arylidenebarbiturates.
Author(s)
Ejaz Ahmed Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan
Ahsan Sharif Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan
Shumaila Chohan Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan
Misbahul Ain Khan Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan
Munawar Ali Munawar Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan
Aleeza Farrukh Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan
Robina Begum Institute of Chemistry, University of The Punjab, Lahore, 54590, Pakistan
Nighat Afza Pharmaceutical Research Centre, PCSIR Laboratories Complex, Karachi-75280, Pakistan
Muhammad Ashraf Department of Biochemistry And Biotechnology, The Islamia University, Bahawalpur, Pakistan
Shafia Arshad College of Conventional Medicine, The Islamia University, Bahawalpur, Pakistan
Abstract
A convenient one pot green chemistry route has been developed for the synthesis of 5-arylidenebarbiturates by way of an acetic acid catalyzed Knoevenagel condensation of a variety of aromatic aldehydes with barbituric acid. The target compounds were obtained in 50-90 % yield and characterized by elemental analysis and different spectral techniques such as IR, NMR and EIMS. All of these were screened for antimicrobial activity.
Publication Details
Page(s) 1305-1311
DOI DOI not available
Published Journal: Journal of Chemical Society of Pakistan, Volume: 34, Issue: 5, Year: 2012
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