Author(s):
1. Karima Mohammad Sweify:
Women′s College for Arts, Science and Education, Ain Shams University, Cairo, Egypt
2. Iman Abd El Moneim Darwish:
Women′s College for Arts, Science and Education, Ain Shams University, Cairo, Egypt
3. Dalia Demerdash Abd El Monem Hafez:
Women′s College for Arts, Science and Education, Ain Shams University, Cairo, Egypt
Abstract:
Ivermectin (IVM) is a broad-spectrum anti-parasite agent. It is extremely toxic to fish and aquatic life. Some animals showed reduction in the fertility, the number of variable fetuses and sperm count following treatment with (IVM). Therefore, the objective of the current work was to investigate the mutagenicity of IVM on meiotic chromosomes of mice. The variations in protein fractions of blood serum were also studied using sodium Dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE).Animals received single injections only of 200ug/kg b.wt. for meiotic chromosome study. Whereas single and double treatment for serum protein examinations. Analysis of the treated samples revealed significant increase in meiotic aberrations, 33.83% vs 5.8% for the control (P < 0.001). Single injection induced much variation in the percentage area of the separated protein than that produced by double treatment. These findings supports the mutagenicity of IVM, accordingly cautious use of IVM is advisable.
Page(s):
637-646
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 32, Issue: 2, Year: 2019
Keywords:
Ivermectin IVM
,
quadrivalent ring RIV
,
Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis SDSPAGE
,
percentage area area
,
hexavalent chain CVI
,
sex univalent XY U
,
meiotic preparations
,
Autosome univalent AU
,
quadrivalent chain CIV
References:
References are not available for this document.
Citations
Citations are not available for this document.