Abstract:
Medicinal plants are globally valuable sources of herbal products. A number of studies have been conducted worldwide to confirm their effectiveness. The current study was designed to investigate In Vivo pharmacological investigation of Cordia myxa fruit extracts and synthesis of their ZnO nanoparticles. C. myxa is famously known as Lasura. It isfound in tropical areas of Pakistan and belongs to the family Boraginaceae. After collecting and identifying the plant, fruits of C. myxa were dried under shade for 3-4 weeks and grounded into fine powder. Crude extracts were made in different solvents, including MtOH, EA, DCM, and n- Hex then stored in Eppendorf tubes for further use. Female albino rats weighing 150-250g were used for In Vivo trials. Animals were provided standard lab conditions according to the OECD guidelines. The acute toxicity of C. myxa fruit extracts were observed up to 5g/kg and there was no mortality. So, C. myxa fruit is safe to use. The antipyretic potential of C. myxa fruit extracts were investigated using yeast induced pyrexia method. EA extract of C. myxa exhibited max. antipyretic potential. It showed highly significant results after 1h that maintained up to 3h. EA at a dose level of 500mg/kg possessed antipyretic potential near to the +ve control, paracetamol. General trend against pyrexia was EA> DCM > MtOH >n-Hex. In antidiabetic activity all fruit extracts except n-Hex showed significant results. DCM extract had max. and n-Hex extract had min. potential against diabetes mellitus.Overall trend for antidiabetic activity was DCM > EA > MtOH >n-Hex. C. myxa fruit extracts were also investigated for their anti-inflammatory potential. DCM extract of C. myxa exhibited excellent results against inflammation. Both 400 and 500mg/kg doses were observed as significant doses, but 500 mg/kg dose was more potent. The overall trend for anti-inflammatory activity was DCM > MtOH >n-Hex > EA. Analgesic activity was done by two protocols: hot plate and tail immersion. The general trend in analgesic activity was DCM > EA > MtOH >n-Hex. Powdered crystal ZnO mediated NPs of C. myxa fruit extracts were also prepared and then characterized by UV-Visible spectroscopy and FT-IR spectroscopy. Based on results it is concluded that C. myxa fruit has significant therapeutic properties. This may be a great achievement to obtain a cheap and alternate source of medicine.
Page(s):
83-83
DOI:
DOI not available
Published:
Journal: Abstract Book on Global Science Technology and Management Conference, Volume: 0, Issue: 0, Year: 2023