Thrombocytopenia in the Intensive Care Unit. | [Pakistan Journal of Medical Sciences • 2019]

Author(s):

1. Zohreh Ostadi: Fellowship of Critical Care Medicine, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

2. Kamran Shadvar: Fellowship of Critical Care Medicine, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

3. Sarvin Sanaie: Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

4. Ata Mahmoodpoor: Fellowship of Critical Care Medicine, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

5. Seied Hadi Saghaleini: Fellowship of Critical Care Medicine, Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract:

Thrombocytopenia is a frequent finding in intensive care unit especially among adults and medical ICU patients.Thrombocytopenia is defined as a platelet count less than 100×10 9/l in ICU setting. Platelets are made in the bone marrow from megakaryocytes. Although not fully understood, proplatelets transform into platelets in the lung. The body tries to maintain platelet count relatively constant throughout life. Pathophysiology of thrombocytopenia can be defined by hemodilution, elevated levels of platelet consumption, compromise of platelet production, increased platelet sequestration and increased platelet destruction. Unlike in other situations, absolute platelet count alone does not provide sufficient data in characterizing thrombocytopenia in ICU patients. In such cases, the time course of changes in platelet count is also pivotal. The dynamics of platelet count decrease vary considerably between different ICU patient populations including trauma, major surgery and minor surgery/medical conditions. There are strong evidences available that delay in platelet count restoration in ICU patients is an indicator of a bad outcome.

Page(s): 282-287

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 35, Issue: 1, Year: 2019

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