Alkylation of indole with ß-Aroylacrylic acids and some studies on the alkylated products. | [Journal of Chemical Society of Pakistan • 1987]

Author(s):

1. G. H. Tamam: Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo, Egypt

2. E. A. Soliman: Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo, Egypt

3. A. M. El-Gendy: Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo, Egypt

4. A. Y. El-Kady: Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo, Egypt

Abstract:

ß-aroy1-α--(indole-3-y1) propionic acids (II) were prepared by the reaction of ß-aroyl-acrylic acids (I) with indole. Reaction of (II) with hyridazines afforded the pyridazinones (III) and (IV). Pyridazinone (III) reacted with POC1 ethylbromoacetate and P2S5to yield chloropyridazine (V), 3-0-carbethoxymethyl pyridazine (VIII) and the thione derivatives (XII) respectively. The behaviour of 3-chloropyridazine towards hydrazine hydrate and acyl hydrazines was investigated. Actions of and benzylamine on the 3-0-carbethoxymethyl pyridazine and thione (VIII) and (XII) were also investigated. Dehydration of (II) yielded the butenolide (XV). The behaviour of the butenolide towards benzylamine, ammonium acetate andhydroxylamine hydrochloride was studied.

Page(s): 1-10

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 9, Issue: 1, Year: 1987

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