Thalidomide prevents corneal angiogenesis in an alkali burn model of rabbit corneal neovascularization. | [Journal of Pakistan Medical Association • 2003]

Author(s):

1. A. Abbas: Departments of Ophthalmology. The Aga Khan University, Karachi, Pakistan

2. A. H. Feroze: Departments of Ophthalmology. The Aga Khan University, Karachi, Pakistan

3. G. F. Hyman: Brookdale University Hospital Medical Center, Brooklyn, NY 11212, U.S.A

Abstract:

To determine if Thalidomide has a similar effect in an alkali burn model of corneal Neovascularization, we evaluated the effect of Thalidomide on corneal angiogenesis after alkali corneal burns in rabbits. Twelve rabbits received alkali burns to one cornea. Post injury, four rabbits received oral Thalidomide, 200 mg/kg/day and eight rabbits received placebo (powdered sugar) for thirty days. Assessments were made to quantitate the degree of corneal Neovascularization (NY), the number of clock hours (CH) of limbus involved in NV, the longest NV pedicle (NVP) length and the duration of time required for NV to develop. Thalidomide clearly decreased the area (A) of total NV in the test group (p

Page(s): 83-185

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 53, Issue: 5, Year: 2003

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