Therapeutic effects of mifepristone combined with Gestrinone on patients with endometriosis. | [Pakistan Journal of Medical Research • 2016]

Author(s):

1. Hui-Ling Xue: Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei Province, P. R. China

2. Ning Yu: Department of Obstetrics and Gynecology, People’s Hospital of Yi County, Baoding, Hebei Province, P. R. China

3. Jing Wang: Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei Province, P. R. China

4. Wan-Jiao Hao: Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, P. R. China

5. Ye Li: Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, P. R. China

6. Mei-Yun Liu: Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, P. R. China

Abstract:

Objective: To evaluate the clinical therapeutic effects of mifepristone combined with gestrinone on patients with endometriosis. Methods: A total of 150 endometriotic patients treated in our hospital between January 2014 and December 2015 were randomly divided into a control group and a treatment group (n=75). The control group began to orally take gestrinone capsules on the second day after menstruation started (2.5 mg/time, twice/ week). The treatment group orally took mifepristone tablets (12.5 mg/time, once/day), and the dosage and administration of gestrinone capsules were the same as those of the control group. After 24 weeks of consecutive treatment, the clinical therapeutic effects of the two groups were assessed, and the pelvic symptom score, clinical sign score, serum sex hormone levels and pregnancy outcomes were compared. Results: The total effective rates of control and treatment groups were 77.3% and 90.7% respectively, between which the difference was statistically significant (P

Page(s): 1268-1272

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Research, Volume: 55, Issue: 5, Year: 2016

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