Author(s):
1. Muhammad Khurram Waqas:
Institute of Pharmaceutical Sciences, UVAS, Lahore, Pakistan
2. Sunabal Saleem:
Institute of Pharmaceutical Sciences, UVAS, Lahore, Pakistan
3. Muhammad Ovais Omer:
Department of Pharmacology and Toxicology, UVAS, Lahore, Pakistan
Abstract:
Rheumatoid arthritis (RT) is a progressive disease of the joints in which the joint of the body starts to swell and person faces difficulty in moving and other household tasks if he is not receiving proper treatment and becomes burden on the society socially and economically. The current therapy of the RT mostly lies on its symptomatic treatment with possible side effects. Rheumatoid arthritis is a prevalent autoimmune disease with complex multifactorial etiology. For its treatment the current clinical approaches are focused on the administration of immunosuppressive and Non-steroidal antiinflammatory drugs (NSAIDs). However, the side effects and off targets systemic toxicities of these drugs caused an impaired immune system which may lead other infections. As an alternative system, dietary flavonoids are used as Quercetin but problem is its low bioavailability and therapeutic potential. Hypothesis is that we will enhance the antiinflammatory therapeutic potential of Quercetin by encapsulating in lipids that is green synthesis approach and will have no systemic side effects. Solid lipid nanoparticles (SLNs) were prepared using hot melt encapsulation method. The characterization of solid lipid nano-particles such as FTIR, XRD,SEM were done and after preparation of the SLNs, thirty male albino rats were taken and arthritis were induced in them by FCA model. Quercetin loaded stearic acid nanoparticles were prepared with average size of 100nm, zeta potential of -25mV and quercetin loaded in stearic acid was confirmed by FTIR. The rheumatoid arthritis was significantly (p < 0.001) reduced in the quercetin loaded NPs group by finding out the Inflammatory mediators such as Tumor Necrosis Factor (TNFa) and rheumatoid factor. Hence, it can be concluded that the quercetin loaded stearic acid nanoparticles are very effective and can be replaced the conventional drugs in treating the RA.
Page(s):
56-56
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Sustainable Agriculture and Food Security, August 27-31, 2023 , Volume: 0, Issue: 0, Year: 2023
Keywords:
NSAIDs
,
Quercetin
,
Rheumatoid Arthritis
,
SLNs
,
TNFa
References:
References are not available for this document.
Citations
Citations are not available for this document.