Synthesis and Biological Evaluation of Pyrimidine Based Synthetic Analogues against Oral Bacteria Using in Silico and in vitro Model | [Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23 • 2023]

Author(s):

1. Amanullah: NPRL, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal university D.I.Khan, KPK, Pakistan.

2. Aqsa Ubaid Qaisrani: Department of Chemistry, Qurtaba University, D.I.Khan Campus, Pakistan

3. Niamat Ullah: NPRL, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal university D.I.Khan, KPK, Pakistan.

4. Abdur Rehman: NPRL, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal university D.I.Khan, KPK, Pakistan.

5. Muhammad Imran Aziz: NPRL, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal university D.I.Khan, KPK, Pakistan.

6. Irshad Ullah: NPRL, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal university D.I.Khan, KPK, Pakistan; Department of Pharmacy, University of Swabi, Swabi, Pakistan.

7. Adnan Amin: NPRL, Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal university D.I.Khan, KPK, Pakistan

Abstract:

Oral infections are very common these days, caused by diverse group of microorganism like fungi, virus and bacteria. These infections could be life threatening if not treated early. The aim of the study was to synthesize synthetic analogues for oral bacterial infections which would be safe and cheap. Pyrimidine was used as parent drug and synthetic analogues were prepared using Suzuki coupling reaction. Lipinski rule was applied and all the synthesized analogues were of drug nature. Molecular docking study revealed that all the synthesized analogues shown best fitting with the receptor proteins of the selected bacterial strains. The prepared synthesized analogues were analyzed for antiquorum sensing activity against Chromobacterium voilaceum, antibacterial activity against E. coli, Pseudomonas, Klebsiella and Stapylococcus aureus. 12 analogues were prepared, 5 (R1, R2, Y2, Z2 and Z3) were active against the above said bacteria, and Z2 shown the largest zone of 17mm, 12mm, 9mm, 5mm against E. coli, Klebsiella pneumoniae, Pseudomonas and S. aureus respectively. The MIC of R3 and Z2 against E. coli was 0.78 µgm/ml while Z2 and Z3 shown same results of 3.12 µgm/ml.

Page(s): 61-61

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023

Keywords:

Antimicrobial , Antimicrobial , Oral Infections , Pyrimidine derivatives , In silico analysis

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