Abstract:
Objective: To determine the factors a ecting the procalcitonin level, and its association with the severity of pancreatitis in patients with acute pancreatitis (AP). Study Design: Cross-sectional analytical study. Place and Duration of Study: Division of Gastroenterology, University of Health Sciences, Diyarbak1r Gazi Yasargil Education and Research Hospital and Department of Gastroenterology, Dicle University School of Medicine, Diyarbak1r, Turkey, between April 2017 and June 2021. Methodology: The study included 214 patients diagnosed with AP according to Atlanta criteria. By checking the PCT and CRP values of the patients in the rst 12 hours, the relationship with these scales that predict the severity of pancreatitis was statistically examined. Results: Hundred and fty-two patients (71.0%) had mild, while 62 patients (29.0%) had severe pancreatitis. According to the Atlanta criteria, the mean PCT level of patients with mild pancreatitis was 1.4±0.7 ng/mL, while the mean PCT level of patients with severe pancreatitis was 9.0±12.3 ng/mL (p<0.001). The diagnostic performance of PCT was better for predicting severe AP. For the 0.94 ng/mL cut-o , PCT had 86.9% sensitivity and 50.7% speci city. (AUC=0.731[95% CI: 0.669-0.811]; p<0.001; LR: 1.7). In patients with severe pancreatitis, the PCT level was 4.7±18.5 ng/mL in patients without concomitant infection and 15.8±8.1 ng/mL in patients with concomitant infection (p<0.001). Conclusion: High PCT value measured at the time of the rst admission to the hospital may predict severe pancreatitis. In addition, a high PCT value at the time of admission to the hospital in patients with pancreatitis may indicate another concomitant infection.
Page(s):
1272-1277
DOI:
DOI not available
Published:
Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 32, Issue: 10, Year: 2022
Keywords:
Procalcitonin
,
Acute Pancreatitis
,
Coinfection
,
Severity of pancreatitis