Amino acid substitutions in growth hormone and growth hormone receptor genes mutants in camelus dromedarius | [Pakistan Journal of Zoology • 2020]

Author(s):

1. Sajida Sabahat: Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences,Sheikh Abdul Qadir Jellani Road, Lahore,Pakistan

2. Asif Nadeem: Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences,Sheikh Abdul Qadir Jellani Road, Lahore,Pakistan

3. Maryam Javed: Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences,Sheikh Abdul Qadir Jellani Road, Lahore,Pakistan

4. Muhammad Yasir Zahoor: Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences,Sheikh Abdul Qadir Jellani Road, Lahore,Pakistan

5. Shahid Nabeel: Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences,Sheikh Abdul Qadir Jellani Road, Lahore,Pakistan

6. Abu Saeed Hashmi: Camel Breeding and Research Station,Rakhmani, Bhakkar,Pakistan

Abstract:

The identification of genetic polymorphisms in genes enable us to estimate biological similarities and obtain a better perspective of quantitative traits that play key roles in development and regulating growth. The present study was conducted to characterize genetic variability in the growth hormone (GH) and growth hormone receptor (GHR) of Camelus dromedarius. GH is secreted and synthesized from somatotroph cells of the anterior pituitary lobe and plays significant role in growth, development, metabolism, lactation, and reproduction. Growth hormone interact with GHRs and influence on metabolism and growth. Changes in GHR concentration affect signalling pathways, binding capacity and alters activity of GH. Therefore, the GH and GHR genes are considered important candidate genes. DNA samples of Marecha camel were collected from the Camel Breeding and Research Station at Rakhmani Bhakar, Pakistan. Two significant polymorphic sites were identified in GH gene and three in GHR gene. Out of these, T1720A polymorphism in GH and A211927G polymorphism in GHR genes changed the amino acid from leucine to histidine and methionine to valine, respectively. These polymorphic results suggest that Marecha camel, a major breed in Pakistan, has genetic variability in the GH and GHR genes. These results suggest that Marecha camel has genetic variability in growth-related genes and identified polymorphisms may be helpful for association studies and future selection programs.

Page(s): 49-54

DOI: 10.17582/journal.pjz/2020.52.1.49.54

Published: Journal: Pakistan Journal of Zoology, Volume: 52, Issue: 1, Year: 2020

Keywords:

Growth , GH gene , Polymorphism , GHR gene , Marecha , Camelus dromedarius

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