Advances in metal oxide nanoparticles for cancer therapy and their potential in combating COVID-19 | [Bioscience Research • 2023]

Author(s):

1. Sidra Ahmad: Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan

2. Nayab Ahmad: Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan

3. Shahid Ullah: S-Khan Lab Mardan KPK, Pakistan

4. Saqib Rauf: Center of Omics Sciences Islamia College Peshawar Pakistan

5. Sundus Malik: Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan

6. Muhammad Ijaz: Institute of Integrative Biosciences, CECOS University Peshawar, Pakistan

7. Wajid Ali: Kyber Medical College Peshawar Pakistan

8. Gulzar Ahmad: Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan

9. Luqman Khan: Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan

10. Mamoon Ur Rashid: Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan

Abstract:

Nanoparticles hold potential as versatile tools for combating both cancer and COVID, offering targeted therapies and innovative diagnostic approaches. Recently, nano medicines have received much attention due to their role in the treatment of different types of cancer and viral infections. Nanoparticles can be useful for the treatment of cancer alone or along with other anticancer drugs. In the last couple of years, there has been a rapid and remarkable evolution in the field of nano medicine, primarily fueled by the urgent worldwide demand for innovative technologies aimed at offering preventive and curative solutions against coronavirus disease 2019 (COVID-19). Among different types of nanoparticles, metal and metal oxide nanoparticles have gained significant importance. Different types of therapies are used for the treatment of cancer, but one of the main problems is their side effects on normal healthy cells. Metal oxide nanoparticles have the ability to target only abnormal tumor cells and produce toxicity in them. Metal oxide nanoparticles work through different types of antitumor mechanisms including the generation of ROS, apoptosis, necrosis and interfering in signaling pathways of p53 and other related genes. In this review, we aim to provide an overview of the current knowledge and advancements regarding the potential use of metal oxide nanoparticles for the treatment of cancer and viral infections including COVID19. We have discussed the strategies employed to enhance nanoparticle targeting, drug delivery and therapeutic efficacy for cancer therapy and viral infections. Furthermore, we have addressed the challenges, safety considerations and future directions for the use of metal oxide nanoparticles as potential therapeutic agents.

Page(s): 835-849

DOI: DOI not available

Published: Journal: Bioscience Research, Volume: 20, Issue: 3, Year: 2023

Keywords:

cancer , COVID19 , Zinc oxide nanoparticles , Iron oxide nanoparticles , Copper oxide nanoparticles

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