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Anti-Viral and Acute Toxicity Potential of Octhochloa Compressa from Cholistan Desert
Author(s)
Jawaria Aslam Department of Biochemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Mirza Imran Shahzad Department of Biochemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Tehreem Tahir Department of Biochemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Hina Ashraf Department of Botany,Government Sadiq College Women University, Pakistan
Fiaz-ud-Din Ahmad Department of Pharmacology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Marcello Locatelli Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara
Yasir Arbab Department of physiotherapy, Bahawalpur Medical and Dental College, Pakistan
Sara Tariq Department of Biochemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Fatima Sadiq Department of Biochemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Maria Aslam Department of Computer Science, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Umar Farooq Department of Computer Science, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Abstract
Viral outbreaks are most common cause of mortality and morbidity in human and livestock populations. Due to the lack of effective vaccines and the emergence of new strains of viruses in last few years, there is need to do more research on medicinal plants to find new/novel antiviral agents/templates. Octhochloa compressa (Poaceae) is a Cholistani desert plant traditionally used as a food source and to treat different melodies by local healers. Different extracts of Octhochloa compressa (aqueous (Aqu), methanol (MetOH), n-butanol (n-But), ethyl acetate (EtAc), n-hexane (n-Hex) and dichloromethane (DCM)) were evaluated for anti-viral potential against four important poultry viruses: Avian influenza virus (AIV), infectious bronchitis virus (IBV) New Castle Disease Virus (NDV), and Infectious Bursal Disease Virus (IBDV), grown in 9-11 days old chicken embryonated eggs, and subjected to in ovo anti-viral assays. However, the acute toxicity of MtOH aerial extract was examined in rats. According to the results of antiviral assay, the maximum potential was shown by Aqu and DCM aerial extracts with HA titers 0 (log reduction 10) against AIV strain, while MetOH aerial extract has shown most promising antiviral potential with HA titters 0 (log reduction 10) against IBV strain. In case of IBDV strain, the maximum potential was given by DCM extract with HA titers 2 (log reduction 9), while in case of NDV strain the significant most potential was given by MetOH and EtAc extracts with HA titers 0 (log reduction 10). Hence, the toxicity study revealed that the aerial-MetOH extract of O. compressa extract dose was found to be safe up to 3000 mg/kg and lethal dose (LD50) was found to be 4898.98 mg/kg BW in rats. In conclusion, this preliminary data supports the idea that O. compressa could be used as anti-viral drugs with low toxicity.
Publication Details
Page(s) 67-67
DOI DOI not available
Published Journal: Abstract Book on Global Science Technology and Management Conference, Volume: 0, Issue: 0, Year: 2023
Keywords
Cholistan desert Acute Toxicity Potential Octhochloa Compressa
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