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The preparation of the sustained release Metformin hydrochloride microcapsules by the Wurster fluidized bed.
Author(s)
Jin Cao College of pharmacy, Jiangsu University, Zhenjiang, China
Hongfei Liu College of pharmacy, Jiangsu University, Zhenjiang, China;Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang, China
Weisan Pan Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang, China
Changshan Sun Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang, China
Yingshu Feng Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China
Hui Zhong College of pharmacy, Jiangsu University, Zhenjiang, China
Shuang Shuang Shi College of pharmacy, Jiangsu University, Zhenjiang, China
Yan He School of Chemical Engineering and Light Industry, Guangdong University of Technology, 100 Wai Huan West Road, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, PR China
Abstract
The main objective of this study was to prepare sustained release metformin hydrochloride microcapsules by the Wurster fluidized bed and to obtain the optimized coating process and formulation. Fine microcapsules without agglomeration were obtained in a continuous coating process with the atomization air pressure of 0.2Mpa and an appropriate coating speed temperature. With other design variables of coating process fixed, the effects of different fluidizing air volume, coating temperature, coating speed, coating material, coating materials amount, plasticizer type and plasticizer amount on drug release were investigated respectively. Coating solution was achieved by dissolving EC45cps of 21 g, EC100cps of 7 g, DBS of 2.8 g and talcum powder of 8 g in ethanol to get a final volume of 500 ml. Particles of 150g along with 500mL coating solution would be fine. The results showed that with the air volume of 35 m3 ·h-1, coating temperature of 35o, coating speed of 6 mL·min-1 and proper amount of coating solution, fine microcapsules were obtained. The mean diameter of the microcapsules obtained eventually were 213 µm and the drug content were 23%, which was suitable for producing a suspension. Particle diameter distribution corresponded to the normal distribution and obviously prolonged drug-release was achieved.
Publication Details
Page(s) 779-784
DOI DOI not available
Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 27, Issue: 4, Year: 2014
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