A pragmatic Approach of Genotoxic Monitoring: the Exposure-effect Continuum of Metalworking Fluid with Chromium and Nickel among Machinists at Bearing Manufacturing Industry. | [Asian Journal of Agriculture and Biology • 2018]

Author(s):

1. How Vivien: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

2. Hashim Zailina: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

3. Miswon Nurul Husna: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

4. Lokman Nur Naqibah: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

5. Hashim Nurul Maizura: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

6. Mohd Bashah Nursyahidah: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

7. Nasiruddin Lim Nur Sabrina: Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Abstract:

A pragmatic approach of human biological monitoring was used to measure the exposure level, and examining the blood and urine metabolites (=exposure biomonitoring) which is complemented by estimating the biological effects (=effect biomonitoring). In this cross-sectional study, a total of 53 exposed machinists who were exposed to chromium and nickel in working metal fluids were recruited. The study aimed to determine the different genotoxic endpoints of the metalworking fluid with chromium and nickel by considering the exposure-effect continuum approach. Result showed that the mean values for both the personal air, blood and urine of chromium and nickel concentrations exceeded the reference value. Linear regression analysis showed that both blood and urine chromium is the significant factors for micronuclei and comet tail length formation among machinists.

Page(s): 1-5

DOI: DOI not available

Published: Journal: Asian Journal of Agriculture and Biology, Volume: 0, Issue: S1, Year: 2018

Keywords:

Chromium , Genotoxic Effects , Nickel , exposureeffect continuum

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