Abstract:
Traditional uses of medicinal plants in healthcare practices provide insights into new research areas, and thus their significance is now widely acknowledged. Plants have been the foundation for refined traditional medicine systems such as Ayurvedic, Unani, Chinese medicine, and many others. The current study was designed to investigate In Vivo pharmacological evaluation of different extracts of Caralluma edulis (whole plant) and the synthesis of their ZnO nanoparticle. C. edulis is an edible plant consumed as a vegetable by local people of the Cholistan Desert, and its local name is Pimpa and Seetu. Different extracts of C. edulis were prepared using different solvents such as MtOH, DCM, EA, and n-Hex. All extracts were employed in different In Vivo trials on the Rodent model for study. Female albino rats were used for this evaluation process and provided with standard lab conditions according to the OECD guidelines. No mortality was observed up to the dose level of 5g/kg. The anti-inflammatory potential was investigated using different extracts of C. edulis, and DCM extracts showed max. Anti-inflammatory potential, which is dose-dependent. The general trend of C. edulis extracts against inflammation is DCM> MtOH> EA >n-Hex. The antipyretic potential of C. edulis extracts was investigated using the Yeast-induced pyrexia Model. All extracts showed significant antipyretic potential, which is dose-dependent. Among them, EA extract had max., and n-Hex had a min. antipyretic potential. The overall trend is EA> DCM> MtOH>n-Hex. In antidiabetic activity, all extracts except MtOH showed significant results. EA extract had max. antidiabetic potential while MtOH extract showed no significant changes in the blood glucose level of rats on the first five days after dosing, but on the 7th day, slight changes in the blood glucose level of rats were observed. The overall trend for antidiabetic activity is EA> DCM>n-Hex>MtOH. The analgesic potential of different extracts of C. edulis was evaluated using the Hot plate method and Tail immersion method. The overall trend of different extracts of C.edulis in analgesic activity is DCM>MtOH>EA>n-Hex. Powdered crystal ZnO NPs of C. edulis extracts were also prepared, and their characterization was done using UV-Visible spectroscopy and FT-IR spectroscopy. According to the results of the current study, It is concluded that C. edulis possess strong anti-inflammatory, antipyretic, antidiabetic, and analgesic potential, which proves that it is not only a vegetable with many health benefits but could also be an alternate source of medicine and may also lead to some exceptional drug discovery with no harmful effects.
Page(s):
87-87
DOI:
DOI not available
Published:
Journal: Abstract Book on Global Science Technology and Management Conference, Volume: 0, Issue: 0, Year: 2023