Upfront Nephrectomy Versus Preoperative Chemotherapy in Wilm's Tumour. | [Journal of Ayub Medical College • 2019]

Author(s):

1. Ruqayya Manzoor: Children's Hospital, Pakistan Institute of Medical Sciences, Islamabad-Pakistan

2. Nuzhat Yasmeen: Children's Hospital, Pakistan Institute of Medical Sciences, Islamabad-Pakistan

Abstract:

Background: Wilms tumour is the most common renal tumour in paediatric age group. This study was done to compare the two approaches used for treatment, namely upfront nephrectomy versus pre-operative chemotherapy. Methods; A descriptive cross-sectional study was done enrolling all the patients of Wilms tumour reporting to Oncology unit Children's Hospital during the study period. A total of 80 patients were divided into 2 groups. One group (n=40) had upfront surgery while the other (n=40) received pre-op chemotherapy before surgery. Both groups were compared for outcomes including whether treatment completed and declared cured, lost during treatment against medical advice, or died during treatment. Results; It was found that stage 2 patients were more likely to get upfront surgery done while stage 3, 4 and 5 were likely to get pre-operative chemotherapy before nephrectomy. Also, favourable histology was associated with better outcome overall outcome.

Page(s): 104-107

DOI: DOI not available

Published: Journal: Journal of Ayub Medical College, Volume: 31, Issue: 1, Year: 2019

Keywords:

Keywords are not available for this article.

References:

[1] LazarusJ,KaestnerL, 2010.Wilm's tumour- an update,J Pediatr Sci 2 e26 -

[2] MeshrefM,AlsherifS,KadahS. Comparative, 2014.Study on the Effect of Preoperative Chemotherapy as Recommended in the SIOP Protocols versus the Standard Upfront Surgical Resection in Cases of Stage I, II and Resectable Stage III as Recommended by the NWSG on the Surgical Outcome, Rate of Intra and Postoperative Complication and Percentage of Down Staging in Pediatric Wilm's tumour,Med J Cairo Univ 82 117 -22

[3] AhmedHU,AryaM,TsiourisA,SellaturaySV,ShergillIS,DuffyPG, 2007.An update on the management of Wilm's tumour,Eur J Surg Oncol 33 824 -31

[4] VaranA.,Wilms, 2008.' tumour in children: an overview,Nephron Clin Pract 108 c83 -90

[5] LeeSB,HarberDA, 2001.Wilms' tumour and the WT1 gene,Exp Cell Res 264 74 -99

[6] BhatnagarS., 2009.Management of Wilm's tumour: NWTS vs SIOP,J Indian Assoc Pediatr Surg 14 6 -14

[7] GleasonJM,LorenzoAJ,BowlinPR,KoyleMA, 2014.Innovations in the management of Wilms' tumour,Ther Adv Urol 6 165 -76

[8] CampbellMF,WeinAJ,KavoussiLR,WalshPC, 2007.,CampbellWalsh Urology -

[9] KoEY,RitcheyML, 2009.Current management of Wilms tumour in children,J Pediatr Urol 5 56 -65

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