Abstract:
Edible nanoparticles are being developed for the oral delivery of nutrients to improve human health and well-being. Due to poor physicochemical or biological qualities, the oral bioavailability of active pharmaceutical ingredientsis constantly compromised. Compared to polymeric nanoparticles, food protein nanoparticles offer improved biosafety and cost-effectiveness for oral medication administration. Moreover, diverse food proteins offer "choice and variety" to satisfy the oral delivery issues posed by various medications with poor permeability, low solubility and poor gastrointestinal stability. Due to the availability of amino, hydroxyl and carboxyl groups in dietary proteins, the surface of nanoparticles can be easily modified to impart certain functions. Albeit being in their infancy, food protein nanoparticles have the potential to improve the oral bioavailability of a wide variety of medications, ranging from small molecules to biomacromolecules. Their constituents influence the composition of the gut microbiota and microbial metabolites. The origin, concentration, and amino acid composition of protein nanoparticles are key contributors to intestinal microorganisms' composition, structure, and function. Considering the growing evolution of the sector, it is necessary to investigate the endeavours and mechanisms of food protein nanoparticles in promoting oral bioavailability.
Page(s):
200-200
DOI:
DOI not available
Published:
Journal: Abstract Book on Global Science Technology and Management Conference, Volume: 0, Issue: 0, Year: 2023
Keywords:
Gut microbiota
,
nutrients delivery
,
Protein nanoparticles
,
polymeric nanoparticles