Activity of synergistic combination Amoxy-Cassia against Salmonella. | [Pakistan Journal of Pharmaceutical Sciences • 2007]

Author(s):

1. Nafisa Hassan Ali: Immunology and Infectious Disease Research Laboratory, Department of Microbiology, University of Karachi, Karachi, Pakistan

2. Shahana Urooj Kazmi: Immunology and Infectious Disease Research Laboratory, Department of Microbiology, University of Karachi, Karachi, Pakistan

3. Shaheen Faizi: HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan

Abstract:

The object of this study was to formulate new, cost effective anti-microbial combination for Multi Drug Resistant (MDR) Salmonella enterica Serover Typhi (SEST) based on the synergistic activity of amoxicillin with the aqueous fruit solution of Cassia fistula (CFF), a medicinal plant found in Pakistan which when tested alone have weak antimicrobial activity against blood isolates of MDR SEST. MIC of MDR SEST for amoxicillin and CFF alone was 750 µg/ml and 3750µg/ml. The MIC of amoxicillin in combination with CFF was 23.4-187.5 µg/ml and 0.37-1.56 µg/ml for MDR and MDS SEST respectively. Fractional Inhibitory Concentration Index (FICI) using chequer-board titration suggested synergism for 80% MDR and MDS SEST tested, no antagonism observed. Time kill kinetics showed difference > log2 in CFU of CFF having sub-lethal amoxicillin concentrations. This novel combination is named as Amoxy-cassia. In vivo it is found to be non toxic at 1gm/body weight of mice.

Page(s): 140-145

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 20, Issue: 2, Year: 2007

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