Thyroid Dysfunction and its effect on Serum Lipids. | [Journal of Medical Science • 2015]

Author(s):

1. Shahnaz Attaullah: Department of Bio-Chemistry, Jinnah College for Women, University of Peshawar, Pakistan

2. Imdadullah Mohammadzai: Department of Bio-Chemistry, Jinnah College for Women, University of Peshawar, Pakistan

3. Jawad Ahmad: Department of Bio-Chemistry, Jinnah College for Women, University of Peshawar, Pakistan

4. Bibi Safia Haq: Department of Bio-Chemistry, Jinnah College for Women, University of Peshawar, Pakistan

5. Umair Wadood: Department of Bio-Chemistry, Jinnah College for Women, University of Peshawar, Pakistan

Abstract:

Objectives: To evaluate the incidence of thyroid dysfunction and to investigate the chemical changes in serum lipids under the influence of thyroid dysfunctions. Material and Methods: This study was conducted in Pakistan Medical Research Centre (PMRC), Khyber Medical College, Peshawar, Pakistan from January 2011 to August 2014 . Blood samples and data were collected from patients attending the Institute of Radioactive Nuclear Medicine (IRNUM) Peshawar, Pakistan. A Total of 600 cases were included in this study out of which 214 were euthyroid, 195 and 191 were hyperthyroid and hypothyroid respectively. Results: The study subjects are divided into three groups on the basis of hormonal assay for the three parameters i.e. thyroid stimulating hormone (TSH), tri-iodo thyronine (T3), tetra-iodo thyronine (T4). The Euthyroid group which includes healthy individuals serves as control. The level of significance chosen as 0.05 and p-values were calculated. Conclusion: Thyroid dysfunctions are more prevalent in females, total Cholesterol (TC), Triglyceride (TG) and Low Density Lipo Protein Cholesterol (LDL-C) levels are positively correlated with hyperthyroidism as well as hypothyroidism, whereas High Density Lipo Protein Cholesterol (HDL-C) has no significant relation with thyroid dysfunction.

Page(s): 34-37

DOI: DOI not available

Published: Journal: Journal of Medical Science, Volume: 23, Issue: 1, Year: 2015

Keywords:

Keywords are not available for this article.

References:

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[5] AbramsJJ,GrundySM, 1981.Cholesterol metabolism in hypothyroidism and hyperthyroidism in man,J. Lipid Res 22 323 -38

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